000			a
999			_c18813 _d18813
003			OSt
005			20230206110429.0
008			230206b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_919905 _aShah, Isha
245			_aRole of P-GP inhibitors on gut permeation of metformin: an ex-vivo study
250			_aVol.14(10)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2022
300			_a18-23p.
520			_aObjective: Metformin hydrochloride is a biguanide derivative that is commonly used to treat type 2 diabetes. Metformin has a low oral bioavailability of 50% to 60 %. To overcome these challenges, metformin was used as a Pgp substrate in this research work and used in conjunction with natural P-gp inhibitors.Methods: The study commenced with a chicken non-everted gut sac model that closely resembled in vivo intestinal transport processes. The effect of different P-gp inhibitors on Metformin intestinal permeability was examined in this study to fully recognize the potential significance of Pgp and intestinal metabolism.Results: After evaluating the effectiveness of different P-gp inhibitors at different concentration concentrations i.e. Piperine, Ginger, Drumstick, and Verapamil (standard) at (2 mg/ml, 4 mg/ml, and 6 mg/ml) by non-everted gut sac study. At 2 mg/ml ginger and drumstick could not show any significant improvement. At 4 mg/ml also drumstick could not show any significant improvement in percentage drug permeation. At 6 mg/ml all three natural inhibitors show a significant difference in percentage drug permeation when compared using the f2 similarity index. But piperine was found to be the most potent of all 3 inhibitors because it shows complete release with higher permeation in less time than ginger and drumstick when given in conjunction with Metformin. Then thecomparative permeation study of different concentrations (i.e. 2 mg/ml, 4 mg/ml, and 6 mg/ml) of P-gp inhibitors was carried out using the f2 similarity parameter and was that there is no significant difference in the percentage of drug permeation of Metformin in the presence of 2 mg/mlversus 4 mg/ml inhibitors. The same is with 4 mg/ml versus 6 mg/ml of inhibitors. However, when the percentage drug permeation of Metformin in the presence of 2 mg/ml as compared to 6 mg/ml, a significant difference was observed.Conclusion: It was concluded from this research work that Piperine shows significant improvement in % drug permeation when compared using the f2 similarity index and its formulation with metformin may offer a simple and safe approach to enhance the pharmacological profile of metformin for effective anti-diabetic therapy in humans.
650		0	_94639 _aPHARMACEUTICS
700			_919906 _aVyas, Jigar
773	0		_tInternational journal of pharmacy and pharmaceutical science _x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/45135/27040 _yClick here
942			_2ddc _cAR