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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915542 _a Mallikarjun, G.
245			_aSynthesis of curcumin based imidazo[2,1-b]thiazole derivatives and their biological evaluation as antiproliferative agents
250			_aVol.61, Jan
260			_aNew Delhi _bCSIR _c2022
300			_a13-20p.
520			_aMotivated by the antiproliferative potential of curcumin and imidazothiazoles, a series of curcumin based imidazo[2,1-b] thiazole derivatives have been prepared, characterized and evaluated for their anticancer activity against various human cancer cell lines. These synthesized compounds have been found to have appreciable to moderate activity. Consequently, compounds 8a and 8g display noteworthy cytotoxicity with IC50 values of 7.2 μM and 4.7 μM, respectively, against A549 cell line. Furthermore, compounds 8a, 8b and 8g exhibit substantial cytotoxicity with IC50 values ranging between 9.1 μM to 9.9 μM respectively, against HeLa cell line. Interestingly, compounds 8a and 8g exhibit appreciable cytotoxicity with IC50 values ranging between 7.5 μM to 8.7 μM respectively, against DU145 cancer cell line. Overall, four compunds (8a, 8b, 8g and 8h) demonstrate IC50 values less than 10 μM against selected human cancer cell lines. They could be taken further for investigation of their mode of action and other parameters.
650		0	_95009 _aGENERAL CHEMISTRY
700			_915546 _a Krishnam Raju, A.
773	0		_tIndian journal of chemistry (Section B) _dNew Delhi NISCAIR-CSIR 2005 _x0019-5103
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/60046 _yClick here
942			_2ddc _cAR