000			a
999			_c19211 _d19211
003			OSt
005			20230425112711.0
008			230425b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_920527 _aMadar, Jyoti M.
245			_aSynthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents
250			_aVol.61(2), Feb
260			_aNew Delhi _bCSIR _c2022
300			_a159-173p.
520			_aThe green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential multi-component reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds show potent activity against both Gram positive and Gram negative bacterial and fungal stains. Additionally, anti-inflammatory activity of all the compounds have been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the in vitro antibacterial and anti-inflammatory findings.
650		0	_95009 _aGENERAL CHEMISTRY
700			_915655 _aShastri, Lokesh A.
773	0		_dNew Delhi NISCAIR-CSIR 2005 _tIndian journal of chemistry (Section B) _x0019-5103
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/60711 _yClick here
942			_2ddc _cAR