000			a
999			_c19229 _d19229
003			OSt
005			20230426132046.0
008			230426b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_920560 _aSaini, Ramakrishna
245			_aGreen method for the synthesis of isoxazolyl aryl thieno[2,3-d]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity
250			_aVol.61(3), Mar
260			_aNew Delhi _bCSIR _c2022
300			_a336-347p.
520			_aNovel series of isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been synthesized from (E)-2-amino-5-(3-methyl-4-nitroisoxazol-5-yl)-N-(3-methyl-5-styrylisoxazol-4-yl)-4-arylthiophene-3-carboxamide synthon 3. Compound 3 is obtained by reaction of 2-(3-methyl-4-nitro-isoxazol-5-yl)-1-aryl-ethanone 1, N1-{3-methyl-5-[(E)-2-aryl-1-ethenyl]-4-isoxazolyl}-2-cyanoacetamide 2 and elemental sulfur in PEG-400. Isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been obtained from compounds 3 by tandem N-acetylation and cyclodehydration with acetic anhydride. Compounds 3a-q and 4a-q have been characterized by IR, 1H and 13C NMR, and mass spectral data. The title compounds 4a-q have been evaluated for their antimicrobial activity. Compounds 4b, 4c, 4d, 4e, 4j, 4k, 4l and 4m exhibit significant antimicrobial activity, compared to that of standard drugs.
650		0	_95009 _aGENERAL CHEMISTRY
700			_920561 _aMalladi, Srinivas Reddy
773	0		_tIndian journal of chemistry (Section B) _x0019-5103 _dNew Delhi NISCAIR-CSIR 2005
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/61733 _yClick here
942			_2ddc _cAR