000			a
999			_c19241 _d19241
003			OSt
005			20230427102618.0
008			230427b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_920580 _aVatsal, Manu
245			_a1,5-Benzosulfonamide anthracenedione analogues of mitoxantrone as antibacterial and anticancer agents
250			_aVol.61(4), Apr
260			_aNew Delhi _bCSIR _c2022
300			_a442-449p.
520			_aThe new 1,5-disubstituted 9,10 anthraquninone compounds have been synthesized and characterized by FT-IR, 1H and 13C NMR, and mass spectrometry. Mass fragmentation pattern confirms the structure of the synthesized analogues. The synthesized compounds (B1-B5) have been found active against Hela (cervix carcinoma), prostate cancer and breast cancer cell lines in comparison to mitoxantrone. B2 screened out to be best. IC50 value of B2 and mitoxantrone against Hela cell lines have been observed to be 17μg/mL and 2.5μg/mL respectively. DNA intercalation has been proposed as per cell cycle analysis of B2 on Hela cell lines which show major alteration in G0/G1 and S phase. The results are further supported by molecular docking study of (B1-B5) compounds and mitoxantrone with quadruplex terminals i-motif. The compounds have also been evaluated for antibacterial activities.
650		0	_95009 _aGENERAL CHEMISTRY
700			_920581 _aSharma, Anjali
773	0		_x0019-5103 _dNew Delhi NISCAIR-CSIR 2005 _tIndian journal of chemistry (Section B)
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/62579 _yClick here
942			_2ddc _cAR