000			a
999			_c19253 _d19253
003			OSt
005			20230428113705.0
008			230428b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915679 _aDeohate, Pradip P.
245			_aSynthesis of pyrimidine linked heterocyclic scaffolds by intramolecular cyclization and study of biological potential
250			_aVol.61(5), May
260			_aNew Delhi _bCSIR _c2022
300			_a551-557p.
520			_aSynthesis of some interesting pyrimidine linked heterocyclic scaffolds by intramolecular cyclization has been worked out. Initially compound (4,6-dimethyl-pyrimidin-2-yl-amino)-acetic acid hydrazide has been prepared by reacting 2-amino-4,6-dimethyl pyrimidine with ethyl chloroacetate, followed by condensation with hydrazine hydrate. It has then been treated with N-aryl/alkyl isothiocyanates, followed by intramolecular cyclization using alkaline ethanolic solution of I2 with KI, o-phosphoric acid and aqueous KOH to afford respective heterocyclic compounds with differently substituted pharmacophores viz. (5-aryl/alkyl-amino-[1,3,4]-oxadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines, (5-aryl/alkyl-amino-[1,3,4]-thiadiazol-2-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines and (4-aryl/alkyl-5-mercapto-[1,2,4]-triazol-3-yl-methyl)-(4,6-dimethyl-pyrimidin-2-yl)-amines. Developments during the synthesis have been monitored by TLC. Constitution of synthesized compounds have been delineated in accordance with equivalent weight, elemental assay,chemical transformation and IR, 1H NMR and mass spectral investigations. Title compounds have been tested for their biological potential.
650		0	_95009 _aGENERAL CHEMISTRY
700			_915677 _aPalaspagar, Kalpana A.
773	0		_tIndian journal of chemistry (Section B) _x0019-5103 _dNew Delhi NISCAIR-CSIR 2005
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/63648 _yClick here
942			_2ddc _cAR