000			a
999			_c19271 _d19271
003			OSt
005			20230502122013.0
008			230502b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_920625 _aJoshi, Swati
245			_aSynthesis of some ethoxyphthalimide derivatives of pyrazoloisoxazoles and pyrazolopyrimidines and their antimicrobial and anticancer screening
250			_aVol.61(7), Jul
260			_aNew Delhi _bCSIR _c2022
300			_a723-731p.
520			_aSynthesis of 4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one (IIIa-d) has been achieved by the condensation reaction between 5-methyl-2,4-dihydro-3H-pyrazol-3-one (I) and 4-substituted benzaldehydes (IIa-d). Ethyl acetoacetate and hydrazine hydrate in absolute alcohol undergo cyclization reaction to give (I). 4-Arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-ones (IIIa-d) have been converted to corresponding ethoxyphthalimide derivatives (IVa-d) by treatment with phthalimidoxyethyl bromide (A). 1-N-Ethoxyphthalimido-3-methyl-4-(4-substituted benzylidene) pyrazol-5-one (IVa-d) has been reacted with hydroxylamine hydrochloride and guanidine nitrate separately to yield ethoxyphthalimide substituted pyrazolo[3,4-c]isoxazoles (Va-d) and pyrazolo[3,4-d]pyrimidines (VIa-d) respectively. All the compounds have been characterized by elemental and spectral analysis mainly IR, 1H NMR and mass spectroscopy. Synthesized compounds have also been screened for various biological activities viz. antibacterial, antifungal, antiviral and anticancer.
650		0	_95009 _aGENERAL CHEMISTRY
700			_920626 _aTalesara, G. L.
773	0		_dNew Delhi NISCAIR-CSIR 2005 _x0019-5103 _tIndian journal of chemistry (Section B)
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/64633 _yClick here
942			_2ddc _cAR