000			a
999			_c19294 _d19294
003			OSt
005			20230504120144.0
008			230504b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_920665 _aNaaz Farha
245			_aDMAP-catalysed synthesis, antibacterial activity evaluation, cytotoxicity and docking studies of some heterocyclic molecules bearing sulfonamide moiety
250			_aVol.61(9),
260			_aNew Delhi _bCSIR _c2022
300			_a951-960p.
520			_aDMAP has been shown to be a highly efficient nucleophilic catalyst when compared to triethylamine and pyridine using acetonitrile as solvent for the synthesis of a series of novel N- heterocyclic sulfonamide derivatives. The influence of the reaction parameters, like choice of solvent, catalyst, amount of catalyst and reaction time on product yield has been studied. Antibacterial screening involving a range of sulfonamide analogues as new peptide deformylase (PDF) inhibitors have been focused. The molecules show significant antibacterial activity (MIC value 6.2 − 3.1 µg/mL) against B. subtilis, S. pyrogenes, P. vulgaris and P. mirabilis. Potential in silico docking studies have been in conjugation with in vitro antibacterial results. Molecular docking of all compounds with PDF enzyme (PDB code: 1G2A) explain how certain moieties play significant roles in increasing the binding interactions and stabilizing the protein-ligand complexes. The compounds also have confirmed low extent of cytotoxicity when tested on HEL and HeLa cell lines.
650		0	_95009 _aGENERAL CHEMISTRY
700			_920666 _aSrivastava, Ritika
773	0		_x0019-5103 _dNew Delhi NISCAIR-CSIR 2005 _tIndian journal of chemistry (Section B)
856			_uhttp://op.niscpr.res.in/index.php/IJC/article/view/66345 _yClick here
942			_2ddc _cAR