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| 005 | 20230508155012.0 | ||
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| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_920691 _aChoudhary, Sunil Kumar |
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| 245 | _aSynthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole | ||
| 250 | _aVol.61(10), Oct | ||
| 260 |
_aNew Delhi _bCSIR _c2022 |
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| 300 | _a1113-1119p. | ||
| 520 | _aCarbamate derivatives are proved to be an essential class of molecules because of their application as drugs and prodrugs. Their several derivatives also have been used to craft the drug-target interfaces by incorporating the carbamate moiety. Due to the huge demand in pharma-industries these have been extensively explored and synthesized. The synthesis and characterization of carbamate derivatives from 4-amino-1,2,4-triazoles and 3-(methylthio)-4-amino-1,2,4-triazoles are described. Carbamate derivatives of 4-amino-1,2,4-triazoles with phenyl chloroformate in CH3CN using K2CO3 at ca. ~80°C have been synthesized with good to excellent yield (~81 to 97%). The methodology has been subsequently extended for synthesis of carbamate derivatives of 3-(methylthio)-4-amino-1,2,4-triazoles in which bicarbamate derivatives are formed as major products (~39 to 47%) along with mono carbamate derivatives as minor products (~9 to 22%) in the presence of similar solvent and base. On investigating the effect of solvent and base, the reaction in CH3CN in presence of K2CO3 shows the best results. | ||
| 650 | 0 |
_95009 _aGENERAL CHEMISTRY |
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| 700 |
_920692 _aTrivedi, Monika |
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| 773 | 0 |
_dNew Delhi NISCAIR-CSIR 2005 _tIndian journal of chemistry (Section B) _x0019-5103 |
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| 856 |
_uhttp://op.niscpr.res.in/index.php/IJC/article/view/67203 _yClick here |
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_2ddc _cAR |
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