000			a
999			_c19458 _d19458
003			OSt
005			20230526105008.0
008			230526b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_920979 _aKondaveeti, Sreenivasulu Naidu
245			_aDeep insight into the correlation between gut dysbiosis and alzheimer’s amyloidopathy
250			_aVol.13(4), Dec
260			_aNew Delhi _bSAGE _c2022
300			_a305-315p.
520			_aRecent research has shown a strong correlation between gut dysbiosis and Alzheimer’s disease (AD). The purpose of this review is to investigate the relationship between gut dysbiosis, immune system activation, and the onset of AD and to examine current breakthroughs in microbiota-targeted AD therapeutics. A review of scientific literature was conducted to assess the correlation between gut dysbiosis and AD and the various factors associated. Gut dysbiosis produces an increase in harmful substances, such as bacterial amyloids, which makes the gut barrier and blood-brain barrier more permeable. This leads to the stimulation of immunological responses and an increase in cytokines such as interleukin-1β (IL-1β). As a result, gut dysbiosis accelerates the progression of AD. The review highlights the connection between gut dysbiosis and AD and the potential for microbiota-targeted therapies in AD treatment.
650		0	_94774 _aPHARMACOLOGY
700			_919752 _aThekkekkara, Dithu
773	0		_x0976-500X _tJournal of pharmacology and pharmacotherapeutics _dNew Delhi SAGE Publications
856			_uhttps://journals.sagepub.com/doi/epub/10.1177/0976500X221150310 _yClick here
942			_2ddc _cAR