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040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _920988
_aVazhakalayil, Subha Teresa Jose
245 _aComparative study between intravenous clonidine and preservative free intravenous lignocaine in attenuation of pressor response to laryngoscopy and endotracheal intubation
250 _aVol.13(4), Dec
260 _aNew Delhi
_bSAGE
_c2022
300 _a382-387p.
520 _aObjectivesTo compare the attenuation of pressor responses by intravenous clonidine and preservative-free lignocaine to laryngoscopy and endotracheal intubation. Materials and MethodsA randomized, prospective, comparative, double-blinded study was conducted in 80 adult patients who were randomized into two groups of 40 each, group clonidine (Group C) and group lignocaine (Group L). Group C patients were given 2 µg/kg clonidine in 20 ml of normal saline as a slow infusion over 10 min prior to intubation. Group L patients were given 1.5 mg/kg of preservative-free 2% lignocaine in 20 ml of normal saline as a single-dose infusion over 3 min prior to intubation. Baseline vital and hemodynamic parameters were monitored during the perioperative period at 1-, 5-, and 10-min post-intubation. ResultsThe attenuation of heart rate (HR) after intubation was much better with clonidine than lignocaine as there is statistically significant difference in the mean HR between the two groups at 1, 5, and 10 min after intubation with the HR significantly lesser in the Group C than the Group L at all times after intubation. Both clonidine and lignocaine were effective in attenuating systolic blood pressure response after intubation, but clonidine was more effective than lignocaine as systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in the Group C remained much lower than the Group L and the difference between the two groups was statistically significant at all times after intubation.
650 0 _94774
_aPHARMACOLOGY
700 _920989
_aHaroon, Shahbaz
773 0 _dNew Delhi SAGE Publications
_tJournal of pharmacology and pharmacotherapeutics
_x0976-500X
856 _uhttps://journals.sagepub.com/doi/epub/10.1177/0976500X221148539
_yClick here
942 _2ddc
_cAR