000			a
999			_c19473 _d19473
003			OSt
005			20230530093446.0
008			230530b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_921002 _aBaba, Mohammad Zubair
245			_aRole of Nrf2 pathway activation in neurological disorder: a brief review
250			_aVol.13(3), Sep
260			_aNew Delhi _bSAGE _c2022
300			_a229-238p.
520			_aOxidative stress plays a crucial role in the emergence of numerous neurodegenerative diseases, with protein accumulation and mitochondrial damage, which result in neurological disorders. To minimize oxidative stress, several defensive mechanisms protect nerve cells by releasing antioxidants such as nuclear erythroid factor2 (Nrf2)-Kelch-like ECH-associated protein1 (Keap1) signaling pathway activation has been proved to be a prospective treatment to reduce oxidative stress and neuroinflammation for protection of neurons in a variety of neurological disorders. In this review, we focus beneficial role of Nrf2 in Alzheimer’s and Parkinson’s diseases. Nrf2 is proved to be a master regulator of antioxidants by releasing over 250 cytoprotective genes aimed at oxidative stress and neuroinflammation. In animal studies Nrf2 activation is proved to improve autophagy, mitochondrial biogenesis, and Suppression of inflammatory cytokinin which protects neuronal cells and inhibit progressive neurodegeneration.
650		0	_94774 _aPHARMACOLOGY
700			_921003 _aGomathy, S.
773	0		_dNew Delhi SAGE Publications _x0976-500X _tJournal of pharmacology and pharmacotherapeutics
856			_uhttps://journals.sagepub.com/doi/epub/10.1177/0976500X221128855 _yClick here
942			_2ddc _cAR