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_aAIKTC-KRRC _cAIKTC-KRRC |
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_921511 _aYu, X. |
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| 245 | _aBilobalide protects pheochromocytoma cell from oxygen-glucose deprivation/reperfusion induced injury via activating Wnt1/beta catenin pathway | ||
| 250 | _aVol.84(5), Sep-Oct | ||
| 260 |
_aMumbai _bIndian Journal of Pharmaceutical Science _c2022 |
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| 300 | _a1323-1327p. | ||
| 520 | _aTo explore the protective effect of bilobalide on the pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. To simulate ischemia-reperfusion condition, the pheochromocytoma cell injury was induced by oxygen-glucose deprivation/reperfusion in vitro. The cells were divided into control, oxygen-glucose deprivation/reperfusion and oxygen-glucose deprivation/ reperfusion+bilobalide groups. The cell viability, proliferative capacity, malondialdehyde level, superoxide dismutase level, apoptosis, Wnt1 protein level and nuclear beta-catenin protein level were assayed. Compared with control group, the cell viability, proliferative capacity, superoxide dismutase level, Wnt1 protein level and nuclear beta-catenin protein level decreased in the oxygen-glucose deprivation/ reperfusion group, malondialdehyde level and the percentage of apoptotic cells increased in the oxygen- glucose deprivation/reperfusion group, while the cells were treated with bilobalide in the oxygen-glucose deprivation/reperfusion+bilobalide group, all the above-mentioned observation indicators recovered to a certain extent, but still did not reach the level of the control group. Bilobalide protects pheochromocytoma cell from oxygen-glucose deprivation/reperfusion induced injury in vitro through inhibiting oxidative stress via activating Wnt1/beta-catenin pathway. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_921512 _aHou, Jie |
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| 773 | 0 |
_tIndian journal of pharmaceutical sciences _dNew Delhi Indian Pharmaceutical Association _x0250-474X |
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| 856 |
_uhttps://www.ijpsonline.com/articles/bilobalide-protects-pheochromocytoma-cell-from-oxygenglucose-deprivationreperfusion-induced-injury-emviaem-activating-wn.pdf _yClick here |
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