000			a
999			_c20245 _d20245
003			OSt
005			20231205103905.0
008			231205b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_922301 _a Adhao Vaibhav, S.
245			_aDevelopment and validation of stability indicating high performance liquid chromatography method for determination of leflunomide
250			_aVol.13(2), Apr-Jun
260			_aRaipur _bAsian Pharma Press _c2023
300			_a93-98p.
520			_aA new simple, specific, accurate and precise RP-HPLC method was developed for determination of Leflunomide. In the present study, stress testing of Leflunomide was carried out according to ICH guidelines Q1A (R2). Leflunomide was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Effective separation of drug and degradant was achieved was achieved on a Hypersil BDS C18 column (250mm × 4.6mm, 5.0µ particle size) under specific stress conditions using acetonitrile – 0.02M ammonium acetate buffer (60: 40, v/v) as a solvent system with a flow rate of 1.0mL/min. Quantification and linearity was achieved at 260nm over the concentration range of 5-30µg/mL for Leflunomide. The investigated method was validated as per guidelines.
650		0	_94639 _aPHARMACEUTICS
700			_912265 _aAmbhore, Jaya P.
773	0		_x2231-5667 _dRaipur A & V Publications _tAsian journal of pharmaceutical analysis
856			_uhttps://ajpaonline.com/AbstractView.aspx?PID=2023-13-2-5 _yClick here
942			_2ddc _cAR