| 000 | a | ||
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| 999 |
_c20614 _d20614 |
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| 003 | OSt | ||
| 005 | 20240118121324.0 | ||
| 008 | 240118b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_922813 _aFirouzabadi, Dena |
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| 245 | _aExtensive arm skin necrosis following administration of unfractionated heparin | ||
| 250 | _aVol.55(5), Sep-Oct | ||
| 260 |
_aMumbai _bWolter Kluwer _c2023 |
||
| 300 | _a332-334p. | ||
| 520 | _aUnfractionated heparin (UH), a commonly used anticoagulant, can rarely cause skin necrosis following heparin-induced thrombocytopenia (HIT). A 38-year-old female, a case of chronic inflammatory demyelinating polyneuropathy (CIDP) admitted to the neurology ward, developed extensive skin necrosis following a change in UH dose at the exact site of UH injection. A sudden fall in the platelet count was observed within 48 h of increasing the UH dose. Necrosis of the outer layer of the skin along with clot formation and inflammation in the inner layers was detected after histopathological evaluation. UH was discontinued, and rivaroxaban was started for the patient as soon as the complication was detected. The patient was discharged in good condition after completing treatment for CIDP without any need for surgical removal of the necrotic tissue. Extensive skin necrosis, as a result of HIT, requires immediate discontinuation of UH and substitution of a nonheparin-based anticoagulation treatment. | ||
| 650 | 0 |
_94774 _aPHARMACOLOGY |
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| 700 |
_922814 _aPetramfar, Peyman |
||
| 773 | 0 |
_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613 |
|
| 856 |
_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751520/?report=classic _yClick here |
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| 942 |
_2ddc _cAR |
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