000			a
999			_c20618 _d20618
003			OSt
005			20240118154609.0
008			240118b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_922821 _aAl_Gawhari, Fatima Jalal
245			_aFactors affecting on in vitro release of miconazole from in situ ocular gel
250			_aVol.14(4), Oct-Dec
260			_aMumbai _bWolter Kluwer _c2023
300			_a294-298p.
520			_aThe reason for conducting this study is to prolong release of miconazole in the ocular site of action by ocular‑based gels (OBGs) formulations. The formulation factors affecting on the release from OBG should be studied using various gelling agents in various concentrations to achieve the improvement in retention and residence time in response to prolonged release. In this study, the formulations were prepared using carbopol 940, pectin, sodium alginate, poloxamer 407, and poly(methacrylic acid) at 0.5%, 1%, and 1.5% w/v, respectively. Hydroxypropyl methylcellulose E5 (HPMC E5) 1% was added as thickening agent/viscosity builder. The formulation containing carbopol 940, pectin and sodium alginate at 1.5% w/v, displayed a noticable improvement in viscosity, gelling capacity, and extended release for 7 h in comparison with the reference drug. Overall, the release showed that the sodium alginate with HPMC E5 form in situ gel which had longer time of release reach to 12 h compared with other polymers. the release of miconazole from the OBGs affected significantly by two factors includes gelling capacity and viscosity builder. The novelty of this study is supporting the delivery of ocular drugs through a cornea as an important key of the eye instead of dependence on an internal blood supply using an oral or a parental administration.
650		0	_94639 _aPHARMACEUTICS
773	0		_x2231-4040 _tJournal of advanced pharmaceutical technology and research
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723164/pdf/JAPTR-14-294.pdf _yClick here
942			_2ddc _cAR