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999			_c20683 _d20683
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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_922920 _aKaur, Saini Navjot
245			_aAntidiabetic polyherbal capsule: formulation, evaluation and safety measurements
250			_aVol.85(3), May-Jun
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2023
300			_a686-697p.
520			_aThe well-known plant components for their anti-diabetic properties are Azadirachta indica leaves, Pterocarpus marsupium heartwood, Picrorhiza kurroa rhizomes and Withania coagulans berries and fruit coat. The current study's objective was to create a polyherbal dosage form and assess its effectiveness and stability. The various methanolic extracts of all four medicines were combined in the 1:1:1:1 ratios to create the polyherbal extract. Both in vitro antioxidant and in vitro antidiabetic activity of the extract were evaluated. For their preformulation investigations, a total of six polyherbal compositions were examined. Through Fourier transform infrared spectroscopic analysis, the phytochemicals present were identified. The medication was then put into capsules with a 0 size and evaluated for every aspect of a capsule. The stability of the most recent medicine was examined under diverse circumstances. The 2,2-diphenyl-1- picrylhydrazyl half maximal inhibitory concentration value for the polyherbal extract was 60.56 μg/ml indicating in vitro antioxidant activity. The anti-diabetic action was equivalent to the industry standard and dose-dependent, with an half maximal inhibitory concentration value of 59.82 μg/ml for inhibiting alpha-amylase and 67.28 μg/ml for inhibiting alpha-glucosidase. The polyherbal formulation 1 displayed the best flow qualities. According to Fourier transform infrared spectroscopic data, granules may include terpenes, tannins, phenols and flavonoids. In 30 min, the capsules with polyherbal formulation 1 had a 95.77 % cumulative drug release value. The capsules were discovered to be stable under many types of lighting, however they disintegrate above 70 % humidity and over 55°. As a result, it was discovered that the polyherbal capsules were stable and effective in treating hyperglycemia.
650		0	_94639 _aPHARMACEUTICS
700			_922921 _aSharma, S.
773	0		_x0250-474X _tIndian journal of pharmaceutical sciences _dNew Delhi Indian Pharmaceutical Association
856			_uhttps://www.ijpsonline.com/articles/antidiabetic-polyherbal-capsule-formulation-evaluation-and-safety-measurements-5002.html _yClick here
942			_2ddc _cAR