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040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _923025
_aTamoli, Sanjay Motilal
245 _aNicotine free herbal composition for smoking de-addiction - a placebo controlled, double blind, randomized, multicentric clinical study
250 _aVol.15(2), Apr-Jun
260 _aMumbai
_bWolter Kluwer
_c2023
300 _a88-94p.
520 _aSmoking is a major predisposing factor for many health problems including cancers, vascular disorders, etc., To quit smoking is the only solution to prevent them. Various medicinal and non-medicinal methods are used worldwide for the same. The present study evaluates the effect of a nicotine free herbal formulation containing ingredients like Mucuna pruriens, Withania somnifera, Bacopa monnieri, etc., for cessation of smoking and its effects on other health parameters related to smoking. Materials and Methods: The present study was a placebo controlled, double blind, randomized, and multi-centric clinical study conducted at three clinical sites in India. After ethical approval and informed consent, all participants were given Smotect Tablets or Placebo tablets in a dose of 2 tablets twice daily for 90 days. A total of 103 participants (52 in trial group and 51 in placebo group) completed the study. Evaluation of cessation of smoking was done along with other parameters like measurement of lung capacity, clinical assessment, and laboratory investigations before and after the study. Results: A significant reduction in smoking as well as in the alveolar Carbon monoxide (p < 0.05) and Carboxyhemoglobin levels (p < 0.05) were observed with the use of Smotect tablets as compared to placebo over a period of 90 days. Significant improvement was also observed in quality of life, energy and stamina levels, and reduction of stress level. Smotect tablets were found to be safe without causing any adverse effects.
650 0 _94762
_aBIOCHEMISTRY
700 _923026
_aHarit, Mahesh Kumar
773 0 _x0976-4879
_tJournal of pharmacy and bio allied science
856 _uhttps://journals.lww.com/jpbs/fulltext/2023/15020/nicotine_free_herbal_composition_for_smoking.5.aspx
_yClick here
942 _2ddc
_cAR