000			a
999			_c20817 _d20817
003			OSt
005			20240330102530.0
008			240330b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_923126 _aLuo, Xinyi
245			_aProtective effects of ginsenosides in cisplatin-induced kidney injury _b:A systematic review, meta-analysis
250			_aVol.55(4), Jul-Aug
260			_aMumbai _bWolter Kluwer _c2023
300			_a243-250p.
520			_aAlthough evidence suggests ginsenosides, the primary active and distinctive components of ginseng, have beneficial effects in cisplatin-induced nephrotoxicity, their efficacy and protective mechanisms remain unclear. The aim of the current meta-analysis is to study the effectiveness and mechanisms of ginsenosides in a model of nephrotoxicity induced by cisplatin. Preclinical investigations were conducted in the search of various databases including Medline, Web of Science, Google, CNKI, Embase, and the Wanfang database. 12 studies with 216 animals were included in this review. Stata 15.0 and RevMan 5.3 were used for statistical analyses. The pooled results showed that ginsenosides significantly improved kidney function, and inhibited histological damage. The protective mechanism of ginsenosides is associated with its antioxidative stress, anti-inflammation, anti-apoptosis, and anti-autophagy. The results of our study indicate that ginsenosides have the potential to mitigate nephrotoxicity induced by cisplatin through the modulation of various targets and pathways. Consequently, ginsenosides hold promise as therapeutic agents for the clinical management and prevention of cisplatin-induced nephrotoxicity.
650		0	_94774 _aPHARMACOLOGY
700			_923127 _aXie, Dengpiao
773	0		_tIndian Journal of Pharmacology _dAndheri - Mumbai Wolters Kluwer India Private Limited _x0253-7613
856			_uhttps://journals.lww.com/iphr/fulltext/2023/55040/protective_effects_of_ginsenosides_in.6.aspx _yClick here
942			_2ddc _cAR