000			a
999			_c20840 _d20840
003			OSt
005			20240404094857.0
008			240404b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_923161 _aJia, Liyi
245			_aPharmacological progresses of puerarin in the prevention and treatment of atherosclerosis
250			_aVol.85(4), Jul-Aug
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2023
300			_a884-894p.
520			_aAtherosclerosis is an independent risk factor for cardiovascular diseases, which is related to dyslipidemia, endothelial injury, inflammation, thrombosis, dysfunction of vascular smooth muscle cells and macrophages, etc. Puerarin, a natural monomer from Chinese herb Pueraria lobata, presents multiple cardiovascular protective activities. The paper firstly reviewed the risk factors and drug of atherosclerosis. And then, extraction and synthesis of puerarin were summarized. Especially, it focused on the latest advances in anti-atherosclerosis activities of puerarin from six aspects including lipid-regulating, hyperglycemic, anti- inflammatory, inhibiting thrombosis, promoting microcirculation, improving functions of vascular smooth muscle cells and macrophages. Some novel puerarin derivatives also exhibited favorable anti-atherosclerosis activity. The review would provide new molecular skeletons and lead compounds for anti-atherosclerosis new drug development based on puerarin.
650		0	_94639 _aPHARMACEUTICS
700			_923162 _aXing, Lu.
773	0		_dNew Delhi Indian Pharmaceutical Association _x0250-474X _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/pharmacological-progresses-of-puerarin-in-the-prevention-and-treatment-of-atherosclerosis.pdf _yClick here
942			_2ddc _cAR