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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_923177 _aYanan Liu, Lin Yang
245			_aWalnut green husk extract suppresses ovarian cancer cell proliferation, migration and invasion via modulating microRNA-144-3p
250			_aVol.85(4), Jul-Aug
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2023
300			_a972-978p.
520			_aPrevious reports have indicated that walnut green husk extract has an inhibitory effect on human cancer development. This project aimed to explore the influence of walnut green husk extract on ovarian cancer. SKOV3 cells were exposed to various doses of walnut green husk extract or transfected with microRNA- control or microRNA-144-3p. Meanwhile, anti-microRNA-144-3p or anti-microRNA-control-transfected SKOV3 cells were treated with high-dose walnut green husk extract. Cell counting kit-8, flow cytometry and Transwell monitored cell activity, cycle progression, migration and invasion. Cyclin D1, matrix metallopeptidase 2, matrix metallopeptidase 9, microRNA-144-3p contents were appraised via Western blot or real-time quantitative polymerase chine reaction. After treatment with different concentrations of walnut green husk extract, cell activity, cycle progression, migration, invasion and cyclin D1, matrix metallopeptidase 2 and matrix metallopeptidase 9 protein expression were decreased and microRNA-144-3p level increased in a dose-dependent manner. MicroRNA-144-3p upregulation might hinder cell activity, cycle progression, migration and invasion. Additionally, miR-144-3p knockdown might abolish the repression of high-dose walnut green husk extract on Janus kinase 2 and signal transducer, and activator of transcription 3 expression. Walnut green husk extract might block ovarian cancer development via modulating the microRNA-144-3p/ Janus kinase 2/signal transducer and activator of transcription 3 pathway.
650		0	_94639 _aPHARMACEUTICS
700			_923178 _aGu, Y.
773	0		_x0250-474X _dNew Delhi Indian Pharmaceutical Association _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/walnut-green-husk-extract-suppresses-ovarian-cancer-cell-proliferation-migration-and-invasion-emviaem-modulating-microrn.pdf _yClick here
942			_2ddc _cAR