000			a
999			_c22104 _d22104
003			OSt
005			20250109161851.0
008			250109b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_925057 _aPatil, Jayesh D.
245			_aDevelopment and validation of RP-HPLC and UV spectroscopy method for the determination of diroximel fumarate in bulk drug and pharmaceutical dosage form
250			_aVol.14(3), Jul-Sep
260			_aRaipur _bAsian Pharma Press _c2024
300			_a147-150p.
520			_aTwo new, simple, specific, precise and accurate UV-spectrophotometric and one reverse phase high performance liquid chromatography methods have been developed for the estimation of Diroximel Fumarate in Pharmaceutical dosage form. First UV-spectrophotometric methods show absorption maxima at 253nm for the Diroximel Fumarate. Percentage mean recovery obtained was 100.00%; coefficient of variance was found to be less than 2% and linearity coefficient was 0.9998. Linear response obtained for Diroximel Fumarate was in the concentration range of 0.5-2.5?g/ml. The limit of detection and limit of quantification for Diroximel was found to be 0.049?g/ml and 0.149?g/ml, respectively, and Second RP-HPLC method, chromatography analysis is carried out using Methanol: 10mm of KH2PO4 buffer solution (pH 3.1) (70:30%, v/v) as the mobile phase and C18 Waters (4.6mm x 150mm), 5.0µ column as stationery phase with detection wavelength of 272nm linearity was obtained in the concentration range of 5-25µg/ml for Diroximel Fumarate. Both UV-spectrophotometric and reverse phase high performance liquid chromatography methods were statistically validated according to I.C.H. Guidelines.
650		0	_94642 _aHumanities and Applied Sciences
700			_924937 _aDhankani, Amitkumar R.
773	0		_tAsian journal of pharmaceutical analysis _dRaipur A & V Publications _x2231-5667
856			_uhttps://ajpaonline.com/AbstractView.aspx?PID=2024-14-3-7 _yClick here
942			_2ddc _cAR