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005 | 20250109161851.0 | ||
008 | 250109b xxu||||| |||| 00| 0 eng d | ||
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_aAIKTC-KRRC _cAIKTC-KRRC |
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100 |
_925057 _aPatil, Jayesh D. |
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245 | _aDevelopment and validation of RP-HPLC and UV spectroscopy method for the determination of diroximel fumarate in bulk drug and pharmaceutical dosage form | ||
250 | _aVol.14(3), Jul-Sep | ||
260 |
_aRaipur _bAsian Pharma Press _c2024 |
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300 | _a147-150p. | ||
520 | _aTwo new, simple, specific, precise and accurate UV-spectrophotometric and one reverse phase high performance liquid chromatography methods have been developed for the estimation of Diroximel Fumarate in Pharmaceutical dosage form. First UV-spectrophotometric methods show absorption maxima at 253nm for the Diroximel Fumarate. Percentage mean recovery obtained was 100.00%; coefficient of variance was found to be less than 2% and linearity coefficient was 0.9998. Linear response obtained for Diroximel Fumarate was in the concentration range of 0.5-2.5?g/ml. The limit of detection and limit of quantification for Diroximel was found to be 0.049?g/ml and 0.149?g/ml, respectively, and Second RP-HPLC method, chromatography analysis is carried out using Methanol: 10mm of KH2PO4 buffer solution (pH 3.1) (70:30%, v/v) as the mobile phase and C18 Waters (4.6mm x 150mm), 5.0µ column as stationery phase with detection wavelength of 272nm linearity was obtained in the concentration range of 5-25µg/ml for Diroximel Fumarate. Both UV-spectrophotometric and reverse phase high performance liquid chromatography methods were statistically validated according to I.C.H. Guidelines. | ||
650 | 0 |
_94642 _aHumanities and Applied Sciences |
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700 |
_924937 _aDhankani, Amitkumar R. |
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773 | 0 |
_tAsian journal of pharmaceutical analysis _dRaipur A & V Publications _x2231-5667 |
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856 |
_uhttps://ajpaonline.com/AbstractView.aspx?PID=2024-14-3-7 _yClick here |
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942 |
_2ddc _cAR |