000			a
999			_c7785 _d7785
003			OSt
005			20181205120120.0
008			181205b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_96711 _aNandi, U.
245			_aCompatibility study fo alogliptin benzoate with widely used pharmaceutical excipients for solid dosage form
250			_aVol. 55 (02)
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2018
300			_a20-26
520			_aAlogliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor for oral diabetes care. The present study aims to evaluate the compatibility of alogliptin benzoate with the extensively used pharmaceutical excipients for solid dosage form. This can be achieved by applying Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) techniques together with Fourier-Transform Infrared spectroscopy (FT-IR) as paired technique to aid in the interpretation of outcome. Chosen excipients were Cross carmellose sodium, microcrystalline cellulose, magnesium stearate, sodium starch glycolate, and pregelatinised starch. Results illustrated that drug was compatible with all the excipients except magnesium stearate where a slight degree of physical interaction was observed but mass loss due to degradation was not hastened in TGA. FT-IR study lined out any chemical change of drug with magnesium stearate. These results would be valuable for formulation development of the film coated tablets of alogliptin benzoate.
650		0	_94639 _aPHARMACEUTICS
700			_96713 _aPrakash, A.
700			_96714 _aKumar, R.
773	0		_dMumbai Indian Drug Manufactures Association _tIndian drugs
942			_2ddc _cAR