000			a
999			_c7798 _d7798
003			OSt
005			20181205145952.0
008			181205b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_96763 _aPatil, K. S.
245			_aCognitive enhancing activity of vitis vinifera linn in rats with experimentally induced amnesia and its influence on cholinergic system of brain
250			_aVol. 55 (02) February
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2018
300			_a63-67
520			_aThe present study investigates the effect of ethanolic Vitis vinifera fruit extract on cognitive function in scopolamine, and electroshock induced amnesia in rats. To explore the potential effect, V. vinifera extract was screened by administrating dose (200 mg/kg) for 7 days using scopolamine-induced amnesia model. Cognition parameters were assessed using elevated plus maze and passive avoidance task method with Mentat as standard by using parameters of step down and transfer latency. Acetylcholinesterases enzyme level from brain homogenate was estimated on 7th day. V. vinifera extract (200 mg/kg) showed increase in escape latency (p<0.001) and time spent in target quadrant (p<0.05) while decrease in transfer latency (p<0.001) was observed in scopolamine induced amnesia. Further, pretreatment with V. vinifera (200 mg/kg) significantly reversed the behavioral impairment in scopolamine and electroconvulsive shock induced amnesia. Thus, that ethanolic fruit extract of V. vinifera possesses cognition enhancing property in scopolamine and electroshock induced amnesia models.
650		0	_94639 _aPHARMACEUTICS
700			_96765 _aHadaginal, R. V.
700			_96766 _aWadekar, R. R.
773	0		_tIndian drugs _dMumbai Indian Drug Manufactures Association
942			_2ddc _cAR