000			a
999			_c7837 _d7837
003			OSt
005			20181208100212.0
008			181208b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_96893 _aArchana
245			_aSynthesis and biological evaluation of some novel benzodiazepine containing benzothiazepine/benzoxazepine derivatives as potent anticonvulsant agents
250			_aVol. 55 (06) June
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2018
300			_a7-13
520			_aA new series of 4-benzodiazepinyl-2-( substituted phenyl)-1,5-benzothiazepines (3a-3f) and 4-benzodiazepinyl-2-(substituted phenyl)-1,5-benzoxazepines (4a-4f) were synthesised and evaluated for their anticonvulsant activity. All these compounds were screened in vivo, for their anticonvulsant activity and acute toxicity. Compound 4-benzodiazepinyl-2-(p-methoxy phenyl)-1,5-benzothiazepine 4b, was found to be most potent compoundof this series, more potent than standard drug phenytoin sodium. The homogeneity of all the compounds was checked by TLC. The structures of these compounds have been established by elemental analysis, IR and 1H NMR spectroscopy.
650		0	_94639 _aPHARMACEUTICS
773	0		_dMumbai Indian Drug Manufactures Association _tIndian drugs
942			_2ddc _cAR