| 000 | a | ||
|---|---|---|---|
| 999 |
_c7840 _d7840 |
||
| 003 | OSt | ||
| 005 | 20181208104539.0 | ||
| 008 | 181208b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_96899 _aGadade, D. D. |
||
| 245 | _aSolubility enhancement of ofloxacin by mixed solvency approach | ||
| 250 | _aVol. 55 (06) June | ||
| 260 |
_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2018 |
||
| 300 | _a34-40 | ||
| 520 | _aIn current study we attempted mixed solvency approach for solubility enhancement of poorly water soluble drug, ofloxacin. Various hydrotropic agents including sodium benzoate, urea, sodium citrate, sodium acetate, niaciniamide, Lignocaine hydrochloride, PEG6000, PEG-400 were evaluated under study for enhancing solubility of drug. Further effect of various blends of these hydrotropic agents on solubility of ofloxacin was studied. Aqueous injection of ofloxacin was prepared and evaluated for its antimicrobial effectiveness and stability. It was found that mixed solvency approach is useful in solubility enhancement of ofloxacin without affecting its antimicrobial properties. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_96900 _aLohade, T. S. |
||
| 700 |
_96901 _aLahoti, S. R. |
||
| 773 | 0 |
_dMumbai Indian Drug Manufactures Association _tIndian drugs |
|
| 942 |
_2ddc _cAR |
||