000			a
999			_c7862 _d7862
003			OSt
005			20181210155429.0
008			181210b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_96946 _aSai Priya D.
245			_aNovel Schiff's bases of substituted 2-Amino benzothiazoles: Design, synthesis and antimicrobial activity
250			_aVol. 55 (04) April
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2018
300			_a18-26
520			_aNovel Schiff’s bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was performed by agar diffusion method against a panel of bacterial strains such as S. aureus, B. subtilis (Gram-positive bacteria), E. coli, P. aeruginosa (Gram-negative bacteria) and fungal strains such as C. albicans and A. niger. Compound S13 and S17 had shown potent antifungal activity against C. albicans and A. niger respectively among the novel Schiff’s base compounds when compared to standard, and S13 compound had only shown moderate antibacterial activity against S. aureus amongst all. Molecular docking study was carried out against C. albicans DHFR (Dihydrofolate Reductase) domain to confirm their activity.
650		0	_94639 _aPHARMACEUTICS
653			_a2-amino benzothiazoles
700			_96947 _aKini, S. G.
700			_96948 _aBhatt, V. G.
773	0		_tIndian drugs _dMumbai Indian Drug Manufactures Association
942			_2ddc _cAR