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| 003 | OSt | ||
| 005 | 20190315091909.0 | ||
| 008 | 190306b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_97869 _aChakra, Biplab Kumar |
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| 245 | _aControlled release microsphere formulation of an anti-diabetic drug and characterization of the microsphere | ||
| 250 | _aVol. 10(10), July-August | ||
| 260 |
_aM. P. _bInnovare Academic Sciences Pvt Ltd _c2018 |
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| 300 | _a30-38 | ||
| 520 | _aObjective: Here the objective of this study was to prepare and characterize sustained release metformin loaded microsphere formulation which was prepared by W1/O/W2 emulsion solvent evaporation technique. Methods: Guar gum and sodium alginate were used as a matrix building material, whereas ethyl cellulose was applied as a coating polymer. Here various formulations were prepared by changing the drug and guar gum ratio, and the subsequent drug entrapment efficiency (DEE) and drug release were compared and evaluated. Results: Scanning Electron Microscopy (SEM) studies revealed spherical particles with a smooth appearance. Fourier-transform infrared spectroscopy (FTIR) showed there was no interaction between the ingredients in the final formulation. X-ray Diffraction (XRD) studies showed the emergence of polymorphic forms in the final formulation. The drug entrapment in the final drug loaded microsphere formulations was varied from 30-66.78%. The drug release studies showed the continuous release of the drug through twelve hours. The optimized formulation (f2) found to release 71.5% of drugs at the end of the 12th hour following zero order release kinetics. Conclusion: The increase in gum concentration in the W1 phase, which enhances viscosity in the W1 phase, resulting in an increase in the drug entrapment up to an optimum level and a decrease in the release rate. So, it can prolong the action. So by using this tool, we can say that metformin loaded microsphere formulation would be a suitable pharmaceutical formulation for the treatment of diabetic patients in modern drug therapy for its prolonged action. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_97870 _aSaumen, Karan |
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| 700 |
_97871 _aDas, Biswajit |
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| 773 | 0 |
_x0975 – 1491 _dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/27541/15883 _yClick here |
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| 942 |
_2ddc _cAR |
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