000			a
999			_c8463 _d8463
003			OSt
005			20190315093717.0
008			190307b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_97917 _aSabbir Ahmed
245			_aPhotolytic degradation study on film coated atenolol tablet available in market
250			_aVol. 10(10), July-August
260			_aM. P. _bInnovare Academic Sciences Pvt Ltd _c2018
300			_a6-10
520			_aObjective: Despite its sensitivity to light, atenolol has been manufactured as a film-coated tablet with normal blister packaging by several pharmaceutical companies in Bangladesh. The aim of this study was to investigate the extent of light-induced potency degradation of a randomly selected film coated brand of atenolol. Methods: Atenolol tablets were exposed to different lighting conditions such as normal room light, direct sunlight and different incandescent lights (25W and 40W). Subsequently, UV spectroscopy technique was employed to determine the relative reduction of light absorbance compared to their respective controls. Thereafter, photolytic degradation was calculated by means of the potency reduction of tablets. Results: In all lighting conditions, atenolol tablets underwent exposure dependent gradual decrease in potency. Except for normal room light condition, a significant decrease in potency was found even after 4 to 6 h of exposure to all lighting conditions. After 6 h, potency reduction was found at 40-47%, 26-38% and 34-36% in the samples exposed to direct sunlight, 25 W bulb, and 40 W bulb respectively. Although the shelf life of the film coated tables was 2 y, surprisingly, statistically significant reduction in potency was observed within only 30 d in room light condition. Conclusion: In order to protect from light, blister packaging is not sufficient for film coated atenolol tablets. Photo-stability of all brands of atenolol must be ensured either by protective packaging materials or by optimizing the formulations.
650		0	_94639 _aPHARMACEUTICS
700			_97918 _aMahabubur Rahaman
700			_97919 _aMohammed Faisal
773	0		_tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd _x0975 – 1491
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/26794/15877 _yClick here
942			_2ddc _cAR