| 000 | a | ||
|---|---|---|---|
| 999 |
_c8500 _d8500 |
||
| 003 | OSt | ||
| 005 | 20190315101447.0 | ||
| 008 | 190312b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_97998 _aShehzadi, N. |
||
| 245 | _aRadical scavenging and endogenous defence system inducing activities of 5-[(4-Chlorophenoxy) methyI]-1,3.4-oxadiazole-2-thiol: A novel antioxidant | ||
| 250 | _aVol. 80(6), November-December | ||
| 260 |
_aMumbai _c2018 _bIndian Journal of Pharmaceutical Science |
||
| 300 | _a1125-1135 | ||
| 520 | _a5-[(4-Chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol owing to the presence of –SH group is expected to have a significant reducing potential, which could be translated into antioxidant activity and to prove this, the present study explored the antioxidant potential and binding pattern of this compound to oxidative stress-related protein targets. The antioxidant properties were determined using in vitro methods with ascorbic acid and butylated hydroxytoluene as standards while interactions of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol with protein tyrosine kinase 2-β and glutathione reductase were determined using online software, Mcule 1-Click Docking, 3DLigandSite and COACH. The antioxidant activity of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol was found to be 89.30±0.013, 81.20±0.002, 80.52±0.016, 54.81±0.007, 52.87±0.008, 34.44±0.019 and 19.91±0.014 % in hydrogen peroxide scavenging assay, 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, phosphomolybdenum assay, nitric oxide scavenging assay, reducing power assay, ferric thiocyanate assay and β-carotene bleaching assay, respectively. In all these assays, EC50 of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol ranged from 0.32-0.93 mg/ml. The docking results indicated excellent binding to protein tyrosine kinase 2-β and glutathione reductase, maximum for the latter. The results of the present study revealed that 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol has the propensity to abrogate oxidation by inducing endogenous defence system and preventing radical chain reactions, hence might be considered a potential antioxidant for further investigations. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_97999 _aHussain, K. |
||
| 700 |
_98000 _aKhan, M. T. |
||
| 773 | 0 |
_dNew Delhi Indian Pharmaceutical Association _x0250-474X _tIndian journal of pharmaceutical sciences |
|
| 856 |
_uhttp://www.ijpsonline.com/articles/radical-scavenging-and-endogenous-defence-system-inducing-activities-of-54chlorophenoxymethyl134oxadiazole2thiol-a-novel-antioxida-3572.html _yClick here |
||
| 942 |
_2ddc _cAR |
||