000			a
999			_c8505 _d8505
003			OSt
005			20190315101559.0
008			190312b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98007 _a Vudhgiri, S.
245			_aSynthesis and cytotoxicity evaluation of unusual mixture acid acetate-protected monogalactosyldiacylgly
250			_aVol. 80(6), November-December
260			_aMumbai _c2018 _bIndian Journal of Pharmaceutical Science
300			_a1143-1150
520			_aIn the present study, acetate-protected monogalactosyldiacylglycerol and its fatty acid and aromatic acid analogues were synthesized using trichloroacetimidate methodology. All compounds synthesized were evaluated for cytotoxicity against four cancer cell lines and one normal cell line. Among the compounds tested, mixed acid compound 7b exhibited good activity with IC50 value of 27.5 μM. In a similar manner, the combination of unsaturated oleic acid and cinnamic acid compound 7d also exhibited significant activity with IC50 value 34.9 μM. Based on these results, it could be concluded that the combination of oleic acid with cinnamic acid type acid and other saturated fatty acids enhance the cytotoxicity of glycoglycerolipids.
650		0	_94639 _aPHARMACEUTICS
700			_98008 _aKoude, D.
700			_98009 _aMisra, S.
773	0		_dNew Delhi Indian Pharmaceutical Association _tIndian journal of pharmaceutical sciences _x0250-474X
856			_uhttp://www.ijpsonline.com/articles/synthesis-and-cytotoxicity-evaluation-of-unusual-mixture-acid-acetateprotected-monogalactosyldiacylglycerols-3574.html _yClick here
942			_2ddc _cAR