000			a
999			_c8994 _d8994
003			OSt
005			20190514113640.0
008			190514b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98496 _aChamle, A. H.
245			_aPhotodegradation of Methylcobalamin and Its Determination in a Commercial Formulation
250			_aVol. 81(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a57-62p.
520			_aMethylcobalamin is a highly photolabile and unstable molecule and hence, studies regarding photodegradation of methylcobalamin were carried out. In order to investigate the stability studies, the drug was subjected to photodegradation by exposing it to different light conditions in the validated photostability chamber as per ICH Q1B guideline. The drug was found to be less degraded in the blue light and was more prone to degradation under fluorescent light. Validated stability indicating liquid chromatography method was used for separating the methylcobalamin and its degradation products. The methylcobalamin peak with a retention time of 2.978 min was observed to decrease with a commensurate increase in a degradant peak at 4 min. The observed degradant peak was suspected to be hydroxocobalamin and was further confirmed by molecular weight determination. The fractions collected from high performance liquid chromatography were later injected into mass detector to determine the mass of the degradation products, which was found to be 665.78 amu.
650		0	_94639 _aPHARMACEUTICS
700			_98498 _aShane, N. L. J.
700			_98499 _aPai, A.
773	0		_x0250-474X _dNew Delhi Indian Pharmaceutical Association _tIndian journal of pharmaceutical sciences
856			_uhttp://www.ijpsonline.com/articles/photodegradation-of-methylcobalamin-and-its-determination-in-a-commercial-formulation.pdf _yClick here
942			_2ddc _cAR