000			a
999			_c9038 _d9038
003			OSt
005			20190520102436.0
008			190520b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98622 _aMomin, M.
245			_aSynergistic effect of nigella oil and clotrimazole as ethosomal gel for imporved treatment of fungal infections
250			_aVol. 56(04), April
260			_aMumabi _bIndian Drug Manufacturers Association _c2019
300			_a45-49p.
520			_aThe aim of this research work was to develop an ethosomal gel containing nigella oil encapsulated with clotrimazole (CLT) for improved antifungal activity. The ethosomes were prepared using soya lecithin (SpC) and Nigella oil (NO) as lipids by thin film hydration and they exhibited a particle size of 136±69 nm with an entrapment efficiency of 65.44±1.08 %. CLT ethosomal gel exhibited controlled release of CLT with a steady flux of 7.20mcg/cm2/h across cellophane membrane. The ethosomal gel was stable for 180 days with no significant change in physiochemical parameters. In vitro antifungal activity demonstrated a synergistic action of CLT and NO against the fungal strains compared to plain CLT and NO. This signifies that the combination of NO and CLT in an ethosomal gel has tremendous potential to serve as a synergistic topical anti-fungal preparation than simple ethosomal formulation of CLT.
650		0	_95021 _aDRUG STORE MANAGEMENT
700			_98623 _aButte, K.
700			_98624 _aD'Souza, A.
773	0		_tIndian drugs _dMumbai Indian Drug Manufactures Association
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=OTIy _yClick here
942			_2ddc _cAR