000			a
999			_c9069 _d9069
003			OSt
005			20190523104728.0
008			190523b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98708 _aPawar, Shweta
245			_aFormulation and evaluation of garlic powder loaded floating matrix tablet
250			_aVol. 2(3)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2019
300			_a17-21p.
520			_aObjective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers. Method s: A gastro -retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floati ng time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 3 2 Result s: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT. full factorial designs were used for selection of suitable polymer concentration and effervescent system. No nenteric film coating was applied to mask GP odour . Conclusio n: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formu lation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.
650		0	_94639 _aPHARMACEUTICS
773	0		_x0975 – 1491 _dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/31116/19527 _yClick here
942			_2ddc _cAR