000			a
999			_c9496 _d9496
003			OSt
005			20190919120220.0
008			190919b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_99556 _aHwang, D. I.
245			_aWound Healing Related Biological Activities and Chemical Composition of Absolute from Hemistepta lyrata Bunge Flower
250			_aVol. 81(3), May-June
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a544-550p.
520			_aThe Hemistepta lyrata Bunge flower has various biological and pharmacological effects, but effects of its absolute on skin regeneration or wound healing-linked responses remain unknown. In the present study, effects of Hemistepta lyrata Bunge flower absolute were explored on the proliferation and migration of normal human keratinocytes as well as the composition of absolute from Hemistepta lyrata Bunge flower was analysed using gas chromatography-mass spectrometry. Hemistepta lyrata Bunge flower absolute stimulated both proliferation and migration of the keratinocytes. It also enhanced the phosphorylation of extracellular signal-regulated kinase 1/2 and serine/threonine-specific protein kinase in human keratinocytes. Moreover, the Hemistepta lyrata Bunge flower absolute increased the sprout outgrowth of human keratinocytes. Gas chromatography-mass spectrometry analysis of Hemistepta lyrata Bunge flower absolute allowed identification of 16 compounds. These findings indicated that the absolute promoted the migration and proliferation of keratinocytes. Therefore, Hemistepta lyrata Bunge flower absolute might play a beneficial role in skin regeneration or wound healing by elevating migration and proliferation of keratinocytes.
650		0	_94639 _aPHARMACEUTICS
700			_99557 _aWon, K. J.
773	0		_dNew Delhi Indian Pharmaceutical Association _tIndian journal of pharmaceutical sciences _x0250-474X
856			_uhttp://www.ijpsonline.com/articles/wound-healing-related-biological-activities-and-chemical-composition-of-absolute-from-ihemistepta-lyratai-bunge-flower.pdf _yClick here
942			_2ddc _cAR