000			a
999			_c9810 _d9810
003			OSt
005			20191022142630.0
008			191022b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_910036 _aPalekar, Anusha
245			_aChallenges in Simultaneous Analysis of Hydrolytically Sensitive Ester Drugs in Combined Dosage Forms
250			_aVol.53(1), Jan-Mar
260			_aBengaluru _bIndian journal of pharmaceutical education and research _c2019
300			_a97-103p.
520			_aObjective: Two or more ester drugs in multicomponent formulations are likely to exhibit errors during analysis under acidic conditions, possibly due to hydrolysis. UV Spectrometric methods are hard to disseminate such phenomenon while HPLC methods could provide an insight into possible degradations as source for erroneous conclusions. Material and Methods: Combined dosage formulation of aspirin and clopidogrel bisulphate has been used in the study to demonstrate limitations of popular Absorbance Ratio method commonly used for simultaneous determination by UV spectroscopy. Results:Under acidic hydrolytic conditions, clopidogrel degradation was found to increase in presence of aspirin as shown by HPLC method. Validated HPLC method used for the study comprised of mobile phase methanol: 10 mM phosphate buffer (80:20), pH 7 and a C-18 Column. Rt for aspirin and clopidogrel bisulphate were found to be 2.1 and 7.3 min respectively, with flow rate of 1 mL/min. For absorbance ratio method mixture of methanol: 0.1 N HCl was used as the solvent. Conclusion: In the event of unexpected challenges involving stability of drugs in solutions, it becomes necessary to search for platforms that prevents degradation and subsequently prevent possible interactions between degradants if any
650		0	_94639 _aPHARMACEUTICS
700			_910037 _aKambli, Kshitija
773	0		_tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_53_1_97.pdf _yClick here
942			_2ddc _cAR