000			a
999			_c9814 _d9814
003			OSt
005			20191022152614.0
008			191022b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_910043 _aChattopadhyay, Atiskumar
245			_aEffects of Alprazolam Administration on the Vital Organs of Adult Wister Albino Rats, Biochemical and Toxicological Studies
250			_aVol.53(1), Jan-Mar
260			_aBengaluru _bIndian journal of pharmaceutical education and research _c2019
300			_a127-132p.
520			_aObjective: Effect of Benzodiazepine group of drugs Alprazolam is investigated on different vital organs of Wister albino rat. Materials and Methods: The rats (n=6) were treated with normal doses of Alprazolam for two months along with a placebo group (n=6). After the treatment blood samples were collected and then the rats were sacrificed to collect the tissues of heart, liver and kidney. Results: The levels of enzymes ALT/SGPT, AST/SGOT and the signaling molecule NO were estimated. It was seen that the levels of all these three parameters were increased in all the treated rats. NO is a very important chemical messenger and cellular signaling molecule. Increased level of NO in the tissues of vital organs can modulate the normal physiological and cellular processes and homeostasis of the body in many ways. The NO mediated macrophage activation may also be influenced by the Benzodiazepine (BDZ) group of drugs. So, it’s a very important finding from the clinical point of view. Prolonged use of Alprazolam shows different contraindications and affects different vital organs and systems of the body. To know how the drug affects heart, liver and kidney the levels of two clinically important enzymes like ALT/ SGPT and AST/ SGOT were measured in serum and tissue extracts of rat. These two enzymes are very good indicator of cardiac and hepatic health. Results of the experiments show that levels of both the enzymes were increased in serum and tissue extracts, particularly in the tissue extract of heart. Conclusion: So, from our above studies it can be concluded that there is a relation between increase of NO and the increase of levels of clinically important enzymes. As a result, before frequent and prolonged administration of the drug Alprazolam, further detailed study is needed regarding its effect on different vital organs and cellular and physiological processes.
650		0	_94639 _aPHARMACEUTICS
700			_910044 _aDarbar, Soumendra
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_53_1_127.pdf _yClick here
942			_2ddc _cAR