000			a
999			_c9878 _d9878
003			OSt
005			20191030115752.0
008			191030b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_910157 _aGadhave, R. V.
245			_aDesign, Synthesis, Characterization and biological evaluation of novel benzothiazole based [1,2,4]-triazolo[4,3-A]quinoxaline derivatives
250			_aVol.56(9), Sep
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2019
300			_a22-29p.
520			_aQuinoxaline, triazole and benzothiazole heterocycles plays an important role in modulating biological activity. The present work describes the biological evaluation of target molecules designed using autodock vina docker. Novel benzothiazole based [1, 2, 4]-triazolo [4, 3-a] quinoxalines were synthesized by condensation of substituted 2-amino benzothiazoles and 4-chloro triazoloquinoxalines. The synthesized compounds were characterized by analysis of physical and spectral data. All synthesized compounds were screened for antioxidant activity using 1, 1-Diphenyl-2-picrylhyrazyl radical scavenging, Hydrogen peroxide scavenging and Ferric reducing antioxidant power Method. The compounds 10g and 10i were found to be most active compounds of this series and other compounds showed moderate to less activity when compared with ascorbic acid. Study revealed that the most active compounds after structural modifications can be exploited as lead molecules for other pharmacological activities such as antimicrobial, anti-inflammatory, anticancer and antidepressant, activity
650		0	_94639 _aPHARMACEUTICS
700			_93679 _aKuchekar, B. S.
773	0		_dMumbai Indian Drug Manufactures Association _tIndian drugs
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=OTc1 _yClick here
942			_2ddc _cAR