Formulation of pregabalin-loaded trimethyl chitosan microspheres for nasal drug delivery : in vitro, ex vivo and in vivo characterization
Publication details: Banagalore Association of Pharmaceutical Teachers of India (APTI) 2024Edition: Vol.58(4), Oct-DecDescription: 1215-1224pSubject(s): Online resources: In: Indian journal of pharmaceutical education and researchSummary: Polar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing the brain, limiting emergency seizure treatment. The present study aimed to develop pregabalin-loaded TMC microspheres for intranasal administration in epilepsy. Materials and Methods: The microspheres were prepared by ionotropic gelation method using TMC and glutaraldehyde by varying the formulation and processing parameters and have been characterized for the physicochemical, drug release and pharmacodynamic properties.| Item type | Current library | Status | Barcode | |
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School of Pharmacy Archieval Section | Not for loan | 2025-0299 |
Polar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing the brain, limiting emergency seizure treatment. The present study aimed to develop pregabalin-loaded TMC microspheres for intranasal administration in epilepsy.
Materials and Methods:
The microspheres were prepared by ionotropic gelation method using TMC and glutaraldehyde by varying the formulation and processing parameters and have been characterized for the physicochemical, drug release and pharmacodynamic properties.
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