EVALUATION OF ANTIOXIDANT AND CHEMOPREVE NTIVE POTENTIAL OF M ETHANOLIC EXTRACTS OF LEAF OF AEGLE MARMELOS ATTRIBUTES TOWARDS DUCTAL CARCINOMA STUDIED IN MCF7 CELLS
Arirudran, B.
EVALUATION OF ANTIOXIDANT AND CHEMOPREVE NTIVE POTENTIAL OF M ETHANOLIC EXTRACTS OF LEAF OF AEGLE MARMELOS ATTRIBUTES TOWARDS DUCTAL CARCINOMA STUDIED IN MCF7 CELLS - Vol.11(2) - M P Innovare Academic Sciences Pvt Ltd 2019 - 21-25p.
Objective
:
The objective of the present research work
ha
d been made to evaluate the a
ntioxidant potential along with anti
-cancer
activity
of
methanolic extracts
from
the
leaf
of
A. marmelos
.
Method
s:
Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and
anticancer
activity
in vitro
method
(Cytotoxicity
/MTT assay
and % of cell viability
) by using
MCF7 cell line.
Result
s:
Results of antioxidant efficacy reveal
ed that the IC
50
value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and
20.69% respectively. The methanolic extract of
A
. marmelos
was found to possess
enhanced
anticancer
potential against MCF7 cells. Cytotoxicity
activity of MCF7 cells
, when treated with methanolic
extract of A. marmelos
, was found to be 43.42% at 25μg
, 52.31% at 50μg,
56.31% at 75μg,
58.38% at 100μg
, 62.25% at 125μg. The IC
50
Conclusio
n:
From the
studies
, it was postulated that methanolic extract of leaf from
A. marmelos
has
significant chemopreventive activity. These
specific identities will be useful for the identification and authentication of raw
drug.
PHARMACEUTICS
EVALUATION OF ANTIOXIDANT AND CHEMOPREVE NTIVE POTENTIAL OF M ETHANOLIC EXTRACTS OF LEAF OF AEGLE MARMELOS ATTRIBUTES TOWARDS DUCTAL CARCINOMA STUDIED IN MCF7 CELLS - Vol.11(2) - M P Innovare Academic Sciences Pvt Ltd 2019 - 21-25p.
Objective
:
The objective of the present research work
ha
d been made to evaluate the a
ntioxidant potential along with anti
-cancer
activity
of
methanolic extracts
from
the
leaf
of
A. marmelos
.
Method
s:
Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and
anticancer
activity
in vitro
method
(Cytotoxicity
/MTT assay
and % of cell viability
) by using
MCF7 cell line.
Result
s:
Results of antioxidant efficacy reveal
ed that the IC
50
value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and
20.69% respectively. The methanolic extract of
A
. marmelos
was found to possess
enhanced
anticancer
potential against MCF7 cells. Cytotoxicity
activity of MCF7 cells
, when treated with methanolic
extract of A. marmelos
, was found to be 43.42% at 25μg
, 52.31% at 50μg,
56.31% at 75μg,
58.38% at 100μg
, 62.25% at 125μg. The IC
50
Conclusio
n:
From the
studies
, it was postulated that methanolic extract of leaf from
A. marmelos
has
significant chemopreventive activity. These
specific identities will be useful for the identification and authentication of raw
drug.
PHARMACEUTICS