ANTI -CANCER POTENTIAL OF POLYSACCHARIDE ISOLATED FROM METHANOLIC EXTRACT OF TINOSPORA CORDIFOLIASTEM BARK
Ludas, Antony
ANTI -CANCER POTENTIAL OF POLYSACCHARIDE ISOLATED FROM METHANOLIC EXTRACT OF TINOSPORA CORDIFOLIASTEM BARK - Vol.11(5) - M P Innovare Academic Sciences Pvt Ltd 2019 - 43-47p.
Objective:
The exploration of the anticancer potential of polysaccharide isolated from the methanolic extract of
Tinospora
cordifolia
(
T. cordifolia
)
stem bark against breast cancer in DMBA
-induced female albino Wistar rat models were examined by various hematological parameters.
Method
s:
Analysis of Red blood cell (
RBC
), White blood cell (
WBC
) and platelet
level, Tumor markers Carcino
Embryonic Antigen
(CEA) and Cancer
Antigen 15.3 (
CA 15.3) in the serum, was done in the normal, cancer and compound treated rats usin
g specific kits. Histological studies were
performed to examine the changes in the tissue morphology and cell patterns in breast tissue.
Result
s:
The decreased levels of RBC, WBC and platelets in
7,12
-Dimethylbenz
[a]
anthracene (
DMBA
)-induced
breast
cancer
(Group III) animals were
revived to the normal conditions in polysaccharide treated breast cancer (Group IV) animals as that of normal (Group I). The level of tumor markers
CEA
and
CA 15.3, was found elevated in serum of DMBA-
induced breast cancer g
roups (Group III) when compared to their levels in the normal groups
(Group I) whereas polysaccharide treatment (Group IV) prevented this rise in the levels of tumor markers. The histological studies on the breast tissue
samples of all the groups showed th
e appropriate features where the normal (Group I) animals were characterized with
normal cells uniformly
arranged without any change in orientation and morphology, DMBA-
induced cancer (Group III) animals showed
an improper orientation of cells
arranged as
glandular structures, as nest, or cords of various sizes or as solid sheets foci of necrosis in some areas with
margins infiltrating, pushing,
circumcised or mixed and the polysaccharide treated (Group IV) animals showed results resembling that of the norm
al (Group I) animals
PHARMACEUTICS
ANTI -CANCER POTENTIAL OF POLYSACCHARIDE ISOLATED FROM METHANOLIC EXTRACT OF TINOSPORA CORDIFOLIASTEM BARK - Vol.11(5) - M P Innovare Academic Sciences Pvt Ltd 2019 - 43-47p.
Objective:
The exploration of the anticancer potential of polysaccharide isolated from the methanolic extract of
Tinospora
cordifolia
(
T. cordifolia
)
stem bark against breast cancer in DMBA
-induced female albino Wistar rat models were examined by various hematological parameters.
Method
s:
Analysis of Red blood cell (
RBC
), White blood cell (
WBC
) and platelet
level, Tumor markers Carcino
Embryonic Antigen
(CEA) and Cancer
Antigen 15.3 (
CA 15.3) in the serum, was done in the normal, cancer and compound treated rats usin
g specific kits. Histological studies were
performed to examine the changes in the tissue morphology and cell patterns in breast tissue.
Result
s:
The decreased levels of RBC, WBC and platelets in
7,12
-Dimethylbenz
[a]
anthracene (
DMBA
)-induced
breast
cancer
(Group III) animals were
revived to the normal conditions in polysaccharide treated breast cancer (Group IV) animals as that of normal (Group I). The level of tumor markers
CEA
and
CA 15.3, was found elevated in serum of DMBA-
induced breast cancer g
roups (Group III) when compared to their levels in the normal groups
(Group I) whereas polysaccharide treatment (Group IV) prevented this rise in the levels of tumor markers. The histological studies on the breast tissue
samples of all the groups showed th
e appropriate features where the normal (Group I) animals were characterized with
normal cells uniformly
arranged without any change in orientation and morphology, DMBA-
induced cancer (Group III) animals showed
an improper orientation of cells
arranged as
glandular structures, as nest, or cords of various sizes or as solid sheets foci of necrosis in some areas with
margins infiltrating, pushing,
circumcised or mixed and the polysaccharide treated (Group IV) animals showed results resembling that of the norm
al (Group I) animals
PHARMACEUTICS