EFFECT OF BLUMEA LACERA ON TISSUE GSH, LIPID PEROX IDATION AND HEPATIC CELLS IN ETHANOL INDUCED HEPATOTOXICITY IN RATS
Shirode, Devendra S.
EFFECT OF BLUMEA LACERA ON TISSUE GSH, LIPID PEROX IDATION AND HEPATIC CELLS IN ETHANOL INDUCED HEPATOTOXICITY IN RATS - Vol.11(12) - M P Innovare Academic Sciences Pvt Ltd 2019 - 46-50p.
Objective:
To evaluate hepatoprotecti
ve effects of ethanol extract of aerial part of
Blumea lacera
(BLEE) against ethanol
-
induced hepatotoxicity in rats.
Method
s:
The
in vivo
antioxidant activity of BLEE was assessed by determining the tissue g
lutathione (GSH) and lipid peroxidation
(LPO) lev
els. The
BLEE at the doses of 200 and 400
mg/kg and silymarin 100 mg
/kg
administered to the ethanol challenged rats. The effect
s of BLEE and silymarin on
Physical and Biochemical Parameters were measured. Similarly
, histopathological changes of
the liver w
ere studied.
Result
s
:
The BLEE
showed
in vivo
antioxidant activity.
A significant (P<0.001) decrease
in SGOT, SGPT, ALP, total and direct bilirubin
was observed
in BLEE
treated group at doses i.e.
200 mg/kg and 400 mg/kg as compared to intoxicated group.
Liver
damage in animal pretreated with BLEE was
minimal with distinct preservation of structures and the
architectural frame of the hepatic cells.
PHARMACEUTICS
EFFECT OF BLUMEA LACERA ON TISSUE GSH, LIPID PEROX IDATION AND HEPATIC CELLS IN ETHANOL INDUCED HEPATOTOXICITY IN RATS - Vol.11(12) - M P Innovare Academic Sciences Pvt Ltd 2019 - 46-50p.
Objective:
To evaluate hepatoprotecti
ve effects of ethanol extract of aerial part of
Blumea lacera
(BLEE) against ethanol
-
induced hepatotoxicity in rats.
Method
s:
The
in vivo
antioxidant activity of BLEE was assessed by determining the tissue g
lutathione (GSH) and lipid peroxidation
(LPO) lev
els. The
BLEE at the doses of 200 and 400
mg/kg and silymarin 100 mg
/kg
administered to the ethanol challenged rats. The effect
s of BLEE and silymarin on
Physical and Biochemical Parameters were measured. Similarly
, histopathological changes of
the liver w
ere studied.
Result
s
:
The BLEE
showed
in vivo
antioxidant activity.
A significant (P<0.001) decrease
in SGOT, SGPT, ALP, total and direct bilirubin
was observed
in BLEE
treated group at doses i.e.
200 mg/kg and 400 mg/kg as compared to intoxicated group.
Liver
damage in animal pretreated with BLEE was
minimal with distinct preservation of structures and the
architectural frame of the hepatic cells.
PHARMACEUTICS