Protective effects of ficus benghalensis in streptozotocin (STZ) induced diabetic zebrafish (Danio rerio) model
Sabi, Essa M.
Protective effects of ficus benghalensis in streptozotocin (STZ) induced diabetic zebrafish (Danio rerio) model - Vol.56(3), Jul-Sep - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 822-829p.
Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized
by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy,
nephropathy, and retinopathy are associated with DM. Objectives: To explore a
safer treatment option with no/less adverse effects, we evaluated the potential of
Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods:
Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After
induction,
Ficus benghalensis hydroethanolic bark extract was administered to zebrafish
in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such
as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as
alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were
analyzed. Results: Treating the streptozotocin-induced group with
Ficus benghalensis
hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides,
and liver enzymes. The histopathological evaluation also showed improvement in the
damaged pancreatic tissues. Conclusion: Our results suggest that
Ficus benghalensis
hydroethanolic bark extract can be used as a potent therapeutic candidate for treating
diabetes.
PHARMACEUTICS
Protective effects of ficus benghalensis in streptozotocin (STZ) induced diabetic zebrafish (Danio rerio) model - Vol.56(3), Jul-Sep - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 822-829p.
Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized
by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy,
nephropathy, and retinopathy are associated with DM. Objectives: To explore a
safer treatment option with no/less adverse effects, we evaluated the potential of
Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods:
Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After
induction,
Ficus benghalensis hydroethanolic bark extract was administered to zebrafish
in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such
as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as
alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were
analyzed. Results: Treating the streptozotocin-induced group with
Ficus benghalensis
hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides,
and liver enzymes. The histopathological evaluation also showed improvement in the
damaged pancreatic tissues. Conclusion: Our results suggest that
Ficus benghalensis
hydroethanolic bark extract can be used as a potent therapeutic candidate for treating
diabetes.
PHARMACEUTICS