Factors affecting on in vitro release of miconazole from in situ ocular gel
Al_Gawhari, Fatima Jalal
Factors affecting on in vitro release of miconazole from in situ ocular gel - Vol.14(4), Oct-Dec - Mumbai Wolter Kluwer 2023 - 294-298p.
The reason for conducting this study is to prolong release of miconazole in the ocular
site of action by ocular‑based gels (OBGs) formulations. The formulation factors affecting
on the release from OBG should be studied using various gelling agents in various
concentrations to achieve the improvement in retention and residence time in response
to prolonged release. In this study, the formulations were prepared using carbopol 940,
pectin, sodium alginate, poloxamer 407, and poly(methacrylic acid) at 0.5%, 1%, and
1.5% w/v, respectively. Hydroxypropyl methylcellulose E5 (HPMC E5) 1% was added as
thickening agent/viscosity builder. The formulation containing carbopol 940, pectin and
sodium alginate at 1.5% w/v, displayed a noticable improvement in viscosity, gelling
capacity, and extended release for 7 h in comparison with the reference drug. Overall,
the release showed that the sodium alginate with HPMC E5 form in situ gel which had
longer time of release reach to 12 h compared with other polymers. the release of
miconazole from the OBGs affected significantly by two factors includes gelling capacity
and viscosity builder. The novelty of this study is supporting the delivery of ocular drugs
through a cornea as an important key of the eye instead of dependence on an internal
blood supply using an oral or a parental administration.
PHARMACEUTICS
Factors affecting on in vitro release of miconazole from in situ ocular gel - Vol.14(4), Oct-Dec - Mumbai Wolter Kluwer 2023 - 294-298p.
The reason for conducting this study is to prolong release of miconazole in the ocular
site of action by ocular‑based gels (OBGs) formulations. The formulation factors affecting
on the release from OBG should be studied using various gelling agents in various
concentrations to achieve the improvement in retention and residence time in response
to prolonged release. In this study, the formulations were prepared using carbopol 940,
pectin, sodium alginate, poloxamer 407, and poly(methacrylic acid) at 0.5%, 1%, and
1.5% w/v, respectively. Hydroxypropyl methylcellulose E5 (HPMC E5) 1% was added as
thickening agent/viscosity builder. The formulation containing carbopol 940, pectin and
sodium alginate at 1.5% w/v, displayed a noticable improvement in viscosity, gelling
capacity, and extended release for 7 h in comparison with the reference drug. Overall,
the release showed that the sodium alginate with HPMC E5 form in situ gel which had
longer time of release reach to 12 h compared with other polymers. the release of
miconazole from the OBGs affected significantly by two factors includes gelling capacity
and viscosity builder. The novelty of this study is supporting the delivery of ocular drugs
through a cornea as an important key of the eye instead of dependence on an internal
blood supply using an oral or a parental administration.
PHARMACEUTICS