Development and characterization of liquisolid compact to improve dissolution of an antihypertensive drug
Kaur, Arvinder
Development and characterization of liquisolid compact to improve dissolution of an antihypertensive drug - Vol.58(4), Oct-Dec - Banagalore Association of Pharmaceutical Teachers of India (APTI) 2024 - 1198-1204p.
The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril.
Objectives:
Utilising various polymers and liquid vehicles, the study’s objective was to develop and characterise Liquisolid compact.
Materials and Methods:
Ramipril liquisolid were formulated using Propylene glycol and PEG 400 as liquid vehicle, MCC as a carrier, Aerosil 200 as a coating material. By using differential scanning calorimetry, the crystallinity of the newly developed drug formulation and the interactions between excipients were investigated. No interaction between the medication and excipients was established by FTIR tests.
PHARMACEUTICS
Development and characterization of liquisolid compact to improve dissolution of an antihypertensive drug - Vol.58(4), Oct-Dec - Banagalore Association of Pharmaceutical Teachers of India (APTI) 2024 - 1198-1204p.
The goal of the current research was to use the straight forward, scalable, and economical Liquisolid compact to improve the dissolution profile of the poorly soluble medication Ramipril.
Objectives:
Utilising various polymers and liquid vehicles, the study’s objective was to develop and characterise Liquisolid compact.
Materials and Methods:
Ramipril liquisolid were formulated using Propylene glycol and PEG 400 as liquid vehicle, MCC as a carrier, Aerosil 200 as a coating material. By using differential scanning calorimetry, the crystallinity of the newly developed drug formulation and the interactions between excipients were investigated. No interaction between the medication and excipients was established by FTIR tests.
PHARMACEUTICS