Design, optimization, and in vitro evaluation of orally disintegrating tablets containing amlodipine besylate
Sevinç, Şahbaz
Design, optimization, and in vitro evaluation of orally disintegrating tablets containing amlodipine besylate - Vol.58(4), Oct-Dec - Banagalore Association of Pharmaceutical Teachers of India (APTI) 2024 - 1205-1214p.
In this study, it was aimed to prepare orally disintegrating tablet formulations of amlodipine besylate by applying the experimental design.
Materials and Methods:
A face-centered, central composite 32 full factorial design was applied to evaluate the effects of filler ratio (MAN: MCC; X1) and super disintegrant percentage (SSG; X2) on the critical tablet characteristics such as tensile strength (Y1), disintegration time (Y2) and dissolution rate (5th min) (Y3).
PHARMACEUTICS
Design, optimization, and in vitro evaluation of orally disintegrating tablets containing amlodipine besylate - Vol.58(4), Oct-Dec - Banagalore Association of Pharmaceutical Teachers of India (APTI) 2024 - 1205-1214p.
In this study, it was aimed to prepare orally disintegrating tablet formulations of amlodipine besylate by applying the experimental design.
Materials and Methods:
A face-centered, central composite 32 full factorial design was applied to evaluate the effects of filler ratio (MAN: MCC; X1) and super disintegrant percentage (SSG; X2) on the critical tablet characteristics such as tensile strength (Y1), disintegration time (Y2) and dissolution rate (5th min) (Y3).
PHARMACEUTICS