Gamma activity model for treatment-resistant bipolar psychotic mania
Kumar, Shashi Ranjan
Gamma activity model for treatment-resistant bipolar psychotic mania - Vol.47(2), Mar-Apr - Mumbai Wolter Kluwer 2015 - 215-218p.
The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
Methods:
Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30–49 Hz gamma spectral power.
Results:
Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
Conclusions:
We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
PHARMACOLOGY
Gamma activity model for treatment-resistant bipolar psychotic mania - Vol.47(2), Mar-Apr - Mumbai Wolter Kluwer 2015 - 215-218p.
The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
Methods:
Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30–49 Hz gamma spectral power.
Results:
Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
Conclusions:
We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
PHARMACOLOGY