Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin
Suresh Kumar
Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin - Vol.47(4), Jul-Aug - Mumbai Wolter Kluwer 2015 - 444-446p.
The brain of mammals contains two major form of cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The dual inhibition of these enzymes is considered as a promising strategy for the treatment of neurological disorder such as Alzheimer's disease (AD), senile dementia, ataxia, and myasthenia gravis. The present study was undertaken to explore the anticholinesterase inhibition property of allicin.
Materials and Methods:
An assessment of cholinesterase inhibition was carried out by Ellman's assay.
Results:
The present study demonstrates allicin, a major ingredient of crushed garlic (Allium sativum L.) inhibited both AChE and BuChE enzymes in a concentration-dependent manner. For allicin, the IC50 concentration was 0.01 mg/mL (61.62 μM) for AChE and 0.05 ± 0.018 mg/mL (308.12 μM) for BuChE enzymes.
PHARMACOLOGY
Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin - Vol.47(4), Jul-Aug - Mumbai Wolter Kluwer 2015 - 444-446p.
The brain of mammals contains two major form of cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The dual inhibition of these enzymes is considered as a promising strategy for the treatment of neurological disorder such as Alzheimer's disease (AD), senile dementia, ataxia, and myasthenia gravis. The present study was undertaken to explore the anticholinesterase inhibition property of allicin.
Materials and Methods:
An assessment of cholinesterase inhibition was carried out by Ellman's assay.
Results:
The present study demonstrates allicin, a major ingredient of crushed garlic (Allium sativum L.) inhibited both AChE and BuChE enzymes in a concentration-dependent manner. For allicin, the IC50 concentration was 0.01 mg/mL (61.62 μM) for AChE and 0.05 ± 0.018 mg/mL (308.12 μM) for BuChE enzymes.
PHARMACOLOGY