SYNTHESIS, SCREENING OF NOVEL 1-SUBSTITUTED-3-(4-OX O-2-PHENYLQUINAZOLIN- 3(4H)-YL) UREA AND THIOUREA ANALOGUES AS POTENT ANT IBACTERIALS (Record no. 11108)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200207120033.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200207b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12001 |
| Author | Dhokale, Sandhya R. |
| 245 ## - TITLE STATEMENT | |
| Title | SYNTHESIS, SCREENING OF NOVEL 1-SUBSTITUTED-3-(4-OX O-2-PHENYLQUINAZOLIN- 3(4H)-YL) UREA AND THIOUREA ANALOGUES AS POTENT ANT IBACTERIALS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(11) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 38-42p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The proposed study is an attempt to determine antib<br/>acterial activity of synthesized novel 1-substitute<br/>d-3-(4-oxo-2-phenylquinazolin-<br/>3(4H)-yl) urea and thiourea analogues as potent anti<br/>bacterials against <br/>S. aureus <br/>and <br/>E. coli <br/>bacteria. <br/>Methods: <br/>The present study reports new series of 1-substitut<br/>ed-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea and t<br/>hiourea derivatives as potent <br/>antibacterial agents. Reagents used in the present <br/>study were of synthetic grade and solvents were use<br/>d after distillation. Novel quinazolinone <br/>analogues were synthesized by considering substitut<br/>ion pattern, characterization of the synthesized an<br/>alogues was performed using various <br/>techniques like Thin layer chromatography, Melting <br/>point, Infrared spectroscopy, Proton NMR spectromet<br/>ry and Mass spectrometry. TLC of the <br/>synthesized analogues was carried out by using (tol<br/>uene: methanol in the ratio 2:1), melting point was<br/> found by open capillary method, IR spectrum <br/>was recorded on JASCO V-530, 1H NMR was recorded on <br/>Bruker Avance Spectrometer and Mass spectra were ob<br/>tained from G6460A, triple <br/>quadrupole/MS/MS system. <br/>In vitro <br/>antibacterial activity was performed against <br/>S. aureus and E. coli.<br/>Results: <br/>Six derivatives of quinazolinone analogues were syn<br/>thesized. The structures of 1-substituted-3-(4-oxo-<br/>2-phenylquinazolin-3(4H)-yl) urea <br/>and thiourea derivatives were confirmed by physical<br/> and spectral analysis. Synthesized molecules showe<br/>d <br/>Rf<br/> of 0.45-0.80 in toluene: methanol <br/>mobile phase, melting point was carried out by open<br/> capillary method and were in range of 90-210 ° C, <br/>IR spectrum was recorded in range of <br/>14000-400 cm<br/>-1<br/>and showed characteristic peaks of NH and of C-O-NH,<br/> 1H NMR of the compounds was distinct to confirm st<br/>ructures with delta <br/>values in the range of 7.53-11.960, Mass spectra pr<br/>oved parent peaks of synthesized compounds confirmi<br/>ng molecular weight. The compounds <br/>were assayed for antibacterial activity against <br/>S. aureus <br/>and<br/> E. coli <br/>using ciprofloxacin as standard. The synthesized an<br/>alogues have shown good <br/>yield and comparable antibacterial |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12002 |
| Co-Author | Thakar, Snehal R. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/35461/21013 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 07/02/2020 | 2020855 | 07/02/2020 | 07/02/2020 | Articles Abstract Database |