IMMUNOMODULATORY, ANTICANCER AND ANTIOXIDANT ACTIVI TIES OF CYCLEA PELTATA (LAM.) HOOK. F. AND THOMSON (Record no. 11122)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200207160822.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200207b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12021 |
| Author | Sony, Jayaraman |
| 245 ## - TITLE STATEMENT | |
| Title | IMMUNOMODULATORY, ANTICANCER AND ANTIOXIDANT ACTIVI TIES OF CYCLEA PELTATA (LAM.) HOOK. F. AND THOMSON |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(10) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 40-46p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: <br/>The present study was performed to evaluate the imm<br/>unomodulatory, anticancer, and antioxidative proper<br/>ties of the fraction (CP_2) <br/>isolated from <br/>Cyclea peltata<br/>. <br/>Methods: <br/>Immunomodulation was evaluated in lymphocytes by ly<br/>mphocyte proliferation assay and in THP-1 macrophag<br/>e cell lines by MTT assay. <br/>The nitrite production by the macrophages was also <br/>measured by the nitrite assay using griess reagent.<br/> The anticancer activity of the fraction was <br/>determined by MTT assay. The antioxidant activity w<br/>as evaluated by DPPH assay and total antioxidant ass<br/>ay by phosphomolybdenum method. It is <br/>expressed as number of gram equivalent of ascorbic <br/>acid. <br/>Results: <br/>The plant fraction showed the presence of flavonoid<br/>s which induced lymphocyte proliferation rate of 4.<br/>29±0.007 at 100 μg/ml. It was not <br/>toxic to THP-1 macrophage cells and also could induc<br/>e nitrite production at 1 mg/ml. It also exhibited <br/>good anticancer activity at 100 μg/ml after <br/>48h of incubation. The DPPH activity was found to be<br/> low since 100 μg/ml showed only an inhibition rate<br/> of 22±0.026. The total antioxidant activity <br/>at 1000 μg/ml of CP_2 was found to be equivalent to<br/> 79±0.03 μg/ml of ascorbic acid exhibiting moderate<br/> antioxidant activity. <br/>Conclusion: <br/>The fraction CP_2 containing flavonoid, isolated fr<br/>om <br/>Cyclea peltata<br/> has good immunomodulatory, antioxidant and antican<br/>cerous property. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12023 |
| Co-Author | Variyar, E. Jayadevi |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| Title | International journal of pharmacy and pharmaceutical science |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/35248/20911 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 07/02/2020 | 2020863 | 07/02/2020 | 07/02/2020 | Articles Abstract Database |